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The Human Predictome

Human protein-protein interactions were predicted using AlphaFold-Multimer in two steps.

Predictions with SPOC >0.86 are 90% confident. For more details, click here.

WARNING: In silico screening has many limitations. The interactions reported on this site are predictions that require experimental validation.

This project was supported by NVIDIA through the NAIRR pilot program led by NSF.

Note that homodimers are excluded from results because they are often artifactually assigned high SPOC/AF-M scores.
Additionally, pairs may not have been run because they were either (not nominated by our classifier KIRC, or they were too large (>3,600 amino acids total)).

Pair Sets

Curated sets of pairs.